Sudden arrhythmic death syndrome

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Clinical characteristics and circumstances of death in the sudden arrhythmic death syndrome.

BACKGROUND Sudden cardiac death (SCD) is a devastating event in the young. Referral to a specialist cardiac pathologist is recommended. Age, sex, and circumstances of death may reflect underlying diagnoses. We aim to describe the demographics of victims and circumstances surrounding sudden cardiac death with a normal heart (ie, sudden arrhythmic death syndrome). METHODS AND RESULTS There were...

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Risk stratification for arrhythmic sudden cardiac death: identifying the roadblocks.

Athough it is difficult to determine the precise number, the range for the number of sudden cardiac deaths (SCDs) per year in the United States alone has been reported from 184 000 to 462 000,1 with estimates that 50% to 70% are due to tachyarrhythmic mechanisms. Regardless of where within this range the true number lies, this represents a large epidemiological problem that warrants serious att...

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Cardiac evaluation of pediatric relatives in sudden arrhythmic death syndrome: a 2-center experience.

BACKGROUND Sudden arrhythmic death syndrome defines a sudden unexpected and unexplained death despite comprehensive pathological and toxicological investigation. Previous studies have focused on evaluation of adult relatives. There is, however, a lack of data in children, leading to highly variable management. We sought to determine the clinical utility of cardiac evaluation in pediatric relati...

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Utility of Post-Mortem Genetic Testing in Cases of Sudden Arrhythmic Death Syndrome

BACKGROUND Sudden arrhythmic death syndrome (SADS) describes a sudden death with negative autopsy and toxicological analysis. Cardiac genetic disease is a likely etiology. OBJECTIVES This study investigated the clinical utility and combined yield of post-mortem genetic testing (molecular autopsy) in cases of SADS and comprehensive clinical evaluation of surviving relatives. METHODS We evalu...

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Sudden arrhythmic death: from basic science to clinical practice

Sudden cardiac death refers to unexpected death attributable to a cardiac cause occurring within 1 h of the onset of symptoms (NICE, 2006). It often results from cardiac arrhythmias and is a major worldwide cause of morbidity and mortality. Arrhythmias account for 180,000 to 250,000 deaths per year in the United States and ∼70,000 deaths per year in the United Kingdom (NICE, 2006; Chugh et al.,...

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ژورنال

عنوان ژورنال: Heart

سال: 2007

ISSN: 1355-6037

DOI: 10.1136/hrt.2006.108134